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A/Prof. Scott G. Wilson, Ph.D.
T +61 8 9346 2466 F +61 8 9346 3221 E scott.wilson(at)uwa.edu.au or scott.2.wilson(at)kcl.ac.uk |
Summary
The goal of our research program is to identify
and elucidate the role of key genes and epigenetic control mechanisms that
affect the development of complex diseases – particularly osteoporosis, thyroid
disease and polycystic ovary syndrome.
The overall objective is to
contribute information that will provide a better understanding of these
diseases and to develop tools of potential use in the diagnosis and/or
treatment of these diseases. To this end, we are following comprehensive
approaches using techniques such as genome-wide screening of family based
cohorts, gene association studies in human population samples and targeted
enrichment bisulfite sequencing of disease discordant monozygotic twins.
Molecular based experimental approaches, which also form part of the program,
employ model cell systems and gene chip technology to study genome wide
expression and the response of genes to pharmacological agents.
Key media
releases (click the item to go to full
story)
Researchers
use whole genome sequencing to uncover new gene controlling
thyroid metabolism
Genes
discovery linked to osteoporosis and fracture risk
Study
identifies genes that control thyroid levels
Link
between period onset and BMI
Genes that 'switch-on' the
reproductive system
Conditions
researched
o
Osteoporosis and Bone Disease
o
Thyroid Disease
o
Polycystic Ovary Syndrome
o
Metabolic Syndrome
o
Thyroid Cancer
o
Liver disease
o
Neurological disease
o
Autoimmune disease
Current research
o
Genetics of osteoporosis
o
Genetics of Polycystic Ovary
Syndrome
o
Genetic control of thyroid
metabolism
o
Genetics of hyperthyroidism
o
Genetics of hypothyroidism
o
Epigenetic regulation of thyroid
function
o
Epigenetic profile and osteoporosis risk
Staff
Full list of staff
and students (click here)
Funding
The Wilson Lab gratefully acknowledges the support of
the following funding agencies:
o
The Australian National Health and
Medical Research Council
o
The
o
Arthritis
o
iVEC/Pawsey
Centre - the Australian Supercomputer Facility,
o
The Department of Health,
Collaborators
o
Professor Tim Spector,
o
Professor John Walsh,
o
A/Professor J. Brent Richards. Department
of Medicine,
o
Professor David Karasik
and Professor Doug Kiel, Institute for Aging Research,
o
Professor Fernando Rivadeneira, Erasmus Medical Centre, The
o
Dr Jordana
Bell, King’s College London, UK.
o
Dr Nicole Soranzo,
The Wellcome Trust Sanger Institute,
o
Professor Frank Dudbridge,
o
Professor Jon Tobias,
o
Dr John Perry,
o
Dr David Chandler, Australian Genome
Research Facility,
o
Dr Nicholas Timpson and Dr Josine Min,
o
Dr
o
Professor Bronwyn Stuckey, Keogh
Institute of Medical Research, WA.
o
Professor Roger Price,
o
Dr Ee Mun Lim and Dr Narrelle Hadlow. PathWest,
Journal peer reviews
Annals of Human Biology, Annals of Human Genetics, American Journal of
Human Genetics, PLoS Genetics, BMC Bioinformatics, Bone, Calcified Tissue
International, Clinical Endocrinology, Human Molecular Genetics, Osteoporosis
International, Twin Research & Human Genetics
Examiner
PhDs: The
Teaching
15 Honours students, 3 PhD students and many undergraduate and summer
school students
‘Big Science’ participation
UK10K – Cohorts Working Group, Wellcome Trust Sanger Institute,
Selected Publications
1: Taylor PN, Porcu
E, Chew S, Campbell PJ, Traglia M,, Brown SJ, Mullin
BH, Shihab HA, Min J, Walter K, Memari
Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta
V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman
D, Panicker V, Perry JRB, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger
D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S,
Walsh JP, Spector TD, Davey Smith G, Durbin R, Richards JB, Sanna
S, Soranzo N, Timpson NJ, Wilson SG and the
UK10K Consortium. Whole genome sequence based analysis of thyroid function. Nat
Commun. 2015 Mar 6;6:5681. doi:
10.1038/ ncomms6681
2: Medici M, Porcu E,
Pistis G, Teumer A, Brown
SJ, Jensen RA, Rawal R, Roef
GL, Plantinga TS, Vermeulen
SH, Lahti J, Simmonds MJ, Husemoen
LL, Freathy RM, Shields BM, Pietzner
D, Nagy R, Broer L, Chaker L,
Korevaar TI, Plia MG, Sala C, Völker U, Richards JB,
Sweep FC, Gieger C, Corre
T, Kajantie E, Thuesen B, Taes YE, Visser WE, Hattersley AT, Kratzsch J,
Hamilton A, Li W, Homuth G, Lobina
M, Mariotti S, Soranzo N, Cocca M, Nauck M, Spielhagen C, Ross A, Arnold A, van de Bunt M, Liyanarachchi S, Heier M, Grabe HJ, Masciullo C, Galesloot TE, Lim EM, Reischl E, Leedman PJ, Lai S, Delitala A, Bremner AP, Philips DI, Beilby
JP, Mulas A, Vocale M, Abecasis G, Forsen T, James A,
Widen E, Hui J, Prokisch H,
Rietzschel EE, Palotie A, Feddema P, Fletcher SJ, Schramm K, Rotter
JI, Kluttig A, Radke D, Traglia M, Surdulescu GL, He H,
Franklyn JA, Tiller D, Vaidya B, de Meyer T, Jørgensen T, Eriksson JG, O'Leary PC, Wichmann
E, Hermus AR, Psaty BM, Ittermann T, Hofman A, Bosi E, Schlessinger D, Wallaschofski H, Pirastu N, Aulchenko YS, de la Chapelle A, Netea-Maier RT, Gough SC, Meyer Zu
Schwabedissen H, Frayling
TM, Kaufman JM, Linneberg A, Räikkönen
K, Smit JW, Kiemeney LA, Rivadeneira F, Uitterlinden AG,
Walsh JP, Meisinger C, den Heijer
M, Visser TJ, Spector TD, Wilson SG, Völzke H, Cappola A, Toniolo D, Sanna S, Naitza S, Peeters RP.
Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS
Genet. 2014 Feb 27;10(2):e1004123.
3: Moayyeri A, Hsu
YH, Karasik D, Estrada K, Xiao SM, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng
HF, Smith AV, Pye SR, Leo PJ, Teumer
A, Hwang JY, Ohlsson C, McGuigan
F, Minster RL, Hayward C, Olmos JM, Lyytikäinen LP,
Lewis JR, Swart KM, Masi L, Oldmeadow
C, Holliday EG, Cheng S, van Schoor NM, Harvey NC,
Kruk M, Del Greco M F, Igl W, Trummer
O, Grigoriou E, Luben R,
Liu CT, Zhou Y, Oei L, Medina-Gomez C, Zmuda J, Tranah G, Brown SJ,
Williams FM, Soranzo N, Jakobsdottir
J, Siggeirsdottir K, Holliday KL, Hannemann
A, Go MJ, Garcia M, Polasek O, Laaksonen
M, Zhu K, Enneman AW, McEvoy
M, Peel R, Sham PC, Jaworski M, Johansson A, Hicks
AA, Pludowski P, Scott R, Dhonukshe-Rutten
RA, van der Velde N, Kähönen M, Viikari JS, Sievänen H, Raitakari OT, González-Macías J, Hernández JL, Mellström D, Ljunggren O, Cho YS,
Völker U, Nauck M, Homuth G, Völzke H, Haring R,
Brown MA, McCloskey E, Nicholson GC, Eastell R, Eisman JA, Jones G, Reid IR, Dennison EM, Wark J, Boonen S, Vanderschueren D, Wu FC, Aspelund
T, Richards JB, Bauer D, Hofman A, Khaw KT, Dedoussis G, Obermayer-Pietsch B, Gyllensten
U, Pramstaller PP, Lorenc
RS, Cooper C, Kung AW, Lips P, Alen M, Attia J, Brandi ML, de Groot LC, Lehtimäki T, Riancho JA, Campbell
H, Liu Y, Harris TB, Akesson K, Karlsson
M, Lee JY, Wallaschofski H, Duncan EL, O'Neill TW, Gudnason V, Spector TD, Rousseau F, Orwoll
E, Cummings SR, Wareham NJ, Rivadeneira F, Uitterlinden AG, Prince RL, Kiel DP, Reeve J, Kaptoge SK. Genetic determinants of heel bone properties:
genome-wide association meta-analysis and replication in the GEFOS/GENOMOS
consortium. Hum Mol Genet. 2014 Jan 26. Epub
4: Menni C, Kastenmüller G, Petersen AK, Bell JT, Psatha
M, Tsai PC, Gieger C, Schulz H, Erte
I, John S, Brosnan MJ, Wilson SG, Tsaprouni L, Lim EM, Stuckey B, Deloukas
P, Mohney R, Suhre K,
Spector TD, Valdes AM. Metabolomic markers reveal
novel pathways of ageing and early development in human populations. Int J Epidemiol. 2013
Aug;42(4):1111-9.
5: Porcu E, Medici M,
Pistis G, Volpato CB, Wilson
SG, Cappola AR, Bos SD,
Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C, Lopez LM, Nolte IM, O'Connell
JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella
C, de Craen AJ, Davies G, de Visser
MC, Ford I, Forsen T, Frayling
TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ,
Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja
R, Netea-Maier RT, Palotie
A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards
JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp
RG, Widen E, Zhai G, Cucca
F, Deary IJ, Eriksson JG, Ferrucci
L, Fox CS, Jukema JW, Kiemeney
LA, Pramstaller PP, Schlessinger
D, Shuldiner AR, Slagboom
EP, Uitterlinden AG, Vaidya
B, Visser TJ, Wolffenbuttel
BH, Meulenbelt I, Rotter
JI, Spector TD, Hicks AA, Toniolo D, Sanna S, Peeters RP, Naitza S. A meta-analysis of thyroid-related traits reveals
novel loci and gender-specific differences in the regulation of thyroid
function. PLoS Genet. 2013;9(2):e1003266.
6: Mullin BH, Mamotte
C, Prince RL, Spector TD, Dudbridge F,
7: Chew S, Dastani Z,
Brown SJ, Lewis JR, Dudbridge F, Soranzo N, Surdulescu GL, Richards JB, Spector TD, Wilson SG.
Copy number variation of the APC gene is associated with regulation of bone
mineral density. Bone. 2012 Nov;51(5):939-43.
8: Zheng HF, Tobias
JH, Duncan E, Evans DM, Eriksson J, Paternoster L, Yerges-Armstrong
LM, Lehtimäki T, Bergström
U, Kähönen M, Leo PJ, Raitakari
O, Laaksonen M, Nicholson GC, Viikari
J, Ladouceur M, Lyytikäinen
LP, Medina-Gomez C, Rivadeneira F, Prince RL, Sievanen H, Leslie WD, Mellström
D, Eisman JA, Movérare-Skrtic
S, Goltzman D, Hanley DA, Jones G, St Pourcain B, Xiao Y, Timpson NJ, Smith GD, Reid IR, Ring SM,
Sambrook PN, Karlsson M,
Dennison EM, Kemp JP, Danoy P, Sayers A, Wilson SG,
Nethander M, McCloskey E, Vandenput
L, Eastell R, Liu J, Spector T, Mitchell BD, Streeten EA, Brommage R, Pettersson-Kymmer U, Brown MA, Ohlsson
C, Richards JB, Lorentzon M. WNT16 influences bone
mineral density, cortical bone thickness, bone strength, and osteoporotic
fracture risk. PLoS Genet. 2012 Jul;8(7):e1002745.
9: Estrada K, Styrkarsdottir
U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri
A, Vandenput L, Willner D,
Xiao SM, Yerges-Armstrong LM, Zheng
HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson
G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ,
Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg
C, Koromila T, Kruk M, Laaksonen
M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen
TV, Nogues X, Patel MS, Prezelj
J, Rose LM, Scollen S, Siggeirsdottir
K, Smith AV, Svensson O, Trompet
S, Trummer O, van Schoor
NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM,
Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford
I, Frost M, Goltzman D, González-Macías
J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD,
Lips P, Ljunggren Ö, Lorenc
RS, Marc J, Mellström D, Obermayer-Pietsch
B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau
F, Slagboom PE, Tang NL, Urreizti
R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg
E, Herrera L, Ingvarsson T, Johannsdottir
H, Kwan T, Li R, Luben R, Medina-Gómez
C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs
JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy
P, Dennison EM, Eastell R, Eisman
JA, Gudnason V, Hofman A,
Jackson RD, Jones G, Jukema JW, Khaw
KT, Lehtimäki T, Liu Y, Lorentzon
M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson
GC, Oostra BA, Peacock M, Pols
HA, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner
AR, Tylavsky FA, van Duijn
CM, Wareham NJ, Cupples LA, Econs
MJ, Evans DM, Harris TB, Kung AW, Psaty BM, Reeve J,
Spector TD, Streeten EA, Zillikens
MC, Thorsteinsdottir U, Ohlsson
C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F. Genome-wide meta-analysis identifies 56 bone
mineral density loci and reveals 14 loci associated with risk of fracture. Nat
Genet. 2012 Apr 15;44(5):491-501.
10: Yang N, Schindeler
A, McDonald MM, Seto JT, Houweling
PJ, Lek M, Hogarth M, Morse AR, Raftery
JM, Balasuriya D, MacArthur DG, Berman Y, Quinlan KG,
Eisman JA, Nguyen TV, Center
JR, Prince RL, Wilson SG, Zhu K, Little DG, North KN. α-Actinin-3
deficiency is associated with reduced bone mass in human and mouse. Bone. 2011
Oct;49(4):790-8.
11: Zhai
G, Teumer A, Stolk L, Perry
JR, Vandenput L, Coviello
AD, Koster A, Bell JT, Bhasin
S, Eriksson J, Eriksson A, Ernst F, Ferrucci L, Frayling TM, Glass D, Grundberg
E, Haring R, Hedman AK, Hofman
A, Kiel DP, Kroemer HK, Liu Y, Lunetta
KL, Maggio M, Lorentzon M, Mangino M, Melzer D, Miljkovic I; MuTHER Consortium, Nica A, Penninx BW, Vasan RS, Rivadeneira F, Small
KS, Soranzo N, Uitterlinden
AG, Völzke H, Wilson SG, Xi L, Zhuang WV, Harris TB, Murabito
JM, Ohlsson C, Murray A, de Jong
FH, Spector TD, Wallaschofski H. Eight common genetic
variants associated with serum DHEAS levels suggest a key role in ageing
mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025.
12: Dudbridge F, Holmans PA, Wilson SG. A flexible model for
association analysis in sibships with missing
genotype data. Ann Hum Genet. 2011 May;75(3):428-38.
13: Hsu YH, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi
EN, Grundberg E, Liang L, Richards JB, Estrada K,
Zhou Y, van Nas A, Moffatt
MF, Zhai G, Hofman A, van Meurs JB, Pols HA, Price RI,
Nilsson O, Pastinen T, Cupples
LA, Lusis AJ, Schadt EE,
Ferrari S, Uitterlinden AG, Rivadeneira
F, Spector TD, Karasik D, Kiel DP. An integration of
genome-wide association study and gene expression profiling to prioritize the
discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS
Genet. 2010 Jun 10;6(6):e1000977.
14: Richards JB, Rivadeneira F, Inouye M, Pastinen
TM, Soranzo N, Wilson SG, Andrew T, Falchi M, Gwilliam R, Ahmadi KR, Valdes AM, Arp P, Whittaker P, Verlaan DJ, Jhamai M, Kumanduri V, Moorhouse M, van Meurs JB, Hofman A, Pols HA, Hart D, Zhai G,
Kato BS, Mullin BH, Zhang F, Deloukas P, Uitterlinden AG, Spector TD. Bone mineral density,
osteoporosis, and osteoporotic fractures: a genome-wide association study.
Lancet. 2008 May 3;371(9623):1505-12.
15: Zhu K, Devine A, Dick IM,
16: Falchi
M,
17: Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG,
Doherty S, Lories RJ, Luyten FP, Gutin
A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart
DJ, Zhang F, Zhai G, Egli
RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide
association scan identifies a prostaglandin-endoperoxide
synthase 2 variant involved in risk of knee
osteoarthritis. Am J Hum Genet. 2008 Jun;82(6):1231-40.
18: Jones MR, Wilson SG,
Mullin BH, Mead R, Dudbridge F, Watts GF, Stuckey BG.Polymorphism
in postinsulin receptor signaling pathway is not
associated with polycystic ovary syndrome. Fertil Steril. 2008 Dec;90(6):2298-303.
19: Devine A,
20: Price P, Olver SD, Silich M, Nador TZ, Yerkovich S, Wilson
SG. Adrenalitis and the adrenocortical
response of resistant and susceptible mice to acute murine
cytomegalovirus infection. Eur J Clin
Invest. 1996 Sep;26(9):811-9.
21:
22: Kent GN, Price RI, Gutteridge DH, Allen JR, Rosman
KJ, Smith M, Bhagat CI, Wilson SG, Retallack RW. Effect of pregnancy and lactation on maternal
bone mass and calcium metabolism. Osteoporos Int.
1993;3 S1:44-7.
See A/Prof
Scott G Wilson at University of Western Australia (click here)
See A/Prof
Scott G Wilson on Google Scholar (click here)